How obesity links with osteoarthritis: mechanic or metabolic?

How obesity links with osteoarthritis: mechanic or metabolic?

Introduction Osteoarthritis (OA) is a highly prevalent joint disease. Obesity is one of the most important risk factors of new-onset OA and deterioration of OA. Obesity was once considered to cause OA simply by added mechanical force. Yet, more recent studies have shown that metabolic factors produced by fat tissue can also initiate inflammatory cascade that consequently can lead to OA. This is...

Inflammatory links between obesity and metabolic disease.

The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Revie...

How Food Industries Can Help in Preventing Childhood Obesity and Metabolic Syndrome?

Intima-Media Thickness in Severe Obesity Links with BMI and metabolic status but not with systemic or adipose tissue inflammation

OBJECTIVEdObesity is associated with cardiovascular risk and a low-grade inflammatory state in both blood and adipose tissue (AT). Whether inflammation contributes to vascular alteration remains an open question. To test this hypothesis, we measured arterial intima-media thickness (IMT), which reflects subclinical atherosclerosis, in severely obese subjects and explored associations with system...

JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction.

Inflammation is thought to underlie the pathogenesis of many chronic diseases. It is now established that obesity results in a state of chronic low-grade inflammation thought to contribute to several metabolic disorders, including insulin resistance and pancreatic islet dysfunction. The protein kinases JNK1 and IKKbeta have been found to serve as critical molecular links between obesity, metabo...